Spike glycoprotein receptor-binding domain (RBD) ya SARS-CoV-2 imayimira kumangidwa kwa tinthu tating'ono ku angiotensin-converting enzyme 2 (ACE2) receptor pamwamba pa maselo amunthu.Chifukwa chake, kuyanjana kwa Spike-ACE2 ndi chinthu chofunikira kwambiri chodziwikiratu kuti ma virus atenga kachilomboka. Gulu latsopano la phylogenetic la SARS-CoV-2 (mzera wa B.1.1.7), womwe umakhala ndi m'malo mwa amino acid mu Spike RBD (N501Y mutation).
Malinga ndi kafukufuku watsopano wochokera ku dipatimenti ya zaumoyo ku UK, kutengera momwe ma genome amayendera, miliri ndi ma modeling, kufalikira kwa mitundu yosiyanasiyana ya SARS-CoV-2 ndi pafupifupi 40-70% kuposa momwe asayansi ena amazindikirira. .Kuyankha mwachangu ndikuzindikira ndi njira imodzi yofunika kwambiri yopewera ndikuwongolera.
Chidachi chimagwiritsidwa ntchito mu vitro qualitative kuzindikira jini ya ORF1ab/N/S ya novel coronavirus 2019-nCoV mu zitsanzo za kupuma, ndikupanga masinthidwe amtundu pa N501Y nthawi imodzi.
Chidachi chimagwiritsa ntchito njira ya ARMS, imatenga S gene ya novel coronavirus (2019-nCoV) ngati dera lomwe mukufuna kusintha masinthidwe, imapanga zoyambira ndi zofufuza za N501Y.
| Zogulitsa | Zofotokozera | Kutentha kwa sitolo | Kufotokozera |
| Real Time PCR Kit ya NovelCoronavirus 2019-nCoV ndiNovel Coronavirus 2019-nCoVKusintha kwa Gene (N501Y) | 48t ndi | -20 ℃ | Analytes: Wild-mtundu wa N501Y,Mtundu wosinthika wa N501Y, ORF1ab,N jini ndi Kuwongolera Kwamkati |
Template Compatibility
- Matenda a Oropharyngeal
- Nasopharyngeal Swab
- Bronchoalveolar Lavage Fluid
- Makoko
Zida Zamagetsi
- RT-PCR reaction buffer
- RT-PCR enzyme mix
- Wild-mtundu positive control
- Kuwongolera kosinthika kosinthika
- Kuwongolera kolakwika
Mtengo wa N501Y
